Cardiff University School of Medicine
The mission of the Centre is to use genetics and genomics to inform our understanding of the aetiology, classification and treatment of major psychiatric disorders, placing it in a unique position to support the CRESTAR project and deliver the project objectives. In our return to RAE 2008 unit UAO 9 (Psychiatry, Neuroscience and Clinical Psychology), 80% of our activity was judged to be internationally excellent (3*) or world leading (4*) placing us joint first in the UK national rankings. MRC CNGG was established in July 2009 with funding from the MRC and Cardiff University to support research infrastructure posts including laboratory management, statistics, public engagement and bioinformatics. The success of the Centre has led to further investment culminating in the recent establishment of the Neuroscience and Mental Health Research Institute (NMHRI), a substantial commitment by the university that enhances the translational capacity of the MRCCNGG and led by Owen. The centre incorporates the Biostatistics Bioinformatics Unit (BBU) which has developed a networked statistical data management system which has sufficient capacity to store, organize, and analyze our GWA studies with funding in place for a new bioinformatics post to underpin our new next generation sequencing work aided by access to sequencers through the Wales Gene Park. In addition to the infrastructure and expertise to support genetic analysis we have access to large and richly-phenotyped clinical samples. Our successful and long-established recruitment procedures and phenotyping experience will ensure we deliver the recruitment targets for this project and this will be further supported by the National Institute of Health and Social Care and Health Research, a new research infrastructure for Wales.