The aim of this WP was to assess pathways and predictors of treatment resistant schizophrenia (TRS, defined as initiation of clozapine) and extreme nonresponse (clozapine-resistant schizophrenia, defined as e.g. clozapine discontinuation, augmentation, hospital admission rates, functional status, assisted living) in schizophrenia based on individual longitudinal population-based registry data from Denmark (population 5.6 Mio). Treatment history included information on prescription drugs over a 15-year period. The unique civil registration number assigned to each resident in Denmark at birth or emigration allowed data linkage between a number of registries providing information on prescription data, somatic and psychiatric hospital admissions, somatic and psychiatric co-morbidity, social status, educational level, family history, mortality, suicide attempts/suicide, employment status, social transfer payments, etc.
In WP6, we assessed pathways and predictors of treatment resistant schizophrenia and extreme non-response in schizophrenia based on individual longitudinal population-based registry data from Denmark (population 5.6 Mio), including the Danish National Newborn Biobank.